Confidence Intervals of Interaction Index for Assessing Multiple Drug Interaction
نویسندگان
چکیده
منابع مشابه
comparative dna interaction studies of antiviral drug, zidovudine and its complex using different instrumental methods
هدف از این مطالعه بررسی امکان استفاده از داروهای شناخته شده در درمان سایر بیماریها به عنوان داروهای ضد سرطان است. همچنین با استفاده از این داروها در ساختمان کمپلکس فلز می توان شاخص های دارویی بدست آمده را بررسی نمود. داروی ضد ویروس ایدز(hiv)به نام زیدوودین(azt)انتخاب و.کمپلکس.محلول.در.آب[pt(azt)2]cl2سنتزو به روشهای مختلف فیزیکی و شیمیایی شناسایی گردید. بر هم کنش مقایسه ای این دارو و کمپلکس پلا...
15 صفحه اولEmax model and interaction index for assessing drug interaction in combination studies.
Applying the Emax model in a Lowe additivity model context, we analyze data from a combination study of trimetrexate (TMQ) and AG2034 (AG) in media of low and high concentrations of folic acid (FA). The Emax model provides a sufficient fit to the data. TMQ is more potent than AG in both low and high FA media. At low TMQ:AG ratios, when a smaller amount of the more potent drug (TMQ) is added to ...
متن کاملImproved Confidence Intervals for the Youden Index
The Youden Index is a summary measurement of the receiver operating characteristic (ROC) curve for the accuracy of a diagnostic test with ordinal or continuous endpoints. The bootstrap confidence interval based on the adjusted proportion estimate was shown to have satisfactory performance among the existing confidence intervals, including the parametric interval via the delta method. In this ar...
متن کاملSample size determination for confidence intervals of interaction effects in moderated multiple regression with continuous predictor and moderator variables.
Moderated multiple regression (MMR) has been widely employed to analyze the interaction or moderating effects in behavior and related disciplines of social science. Much of the methodological literature in the context of MMR concerns statistical power and sample size calculations of hypothesis tests for detecting moderator variables. Notably, interval estimation is a distinct and more informati...
متن کاملComparison of five introduced confidence intervals for the binomial proportion
So far many confidence intervals were introduced for the binomial proportion. In this paper, our purpose is comparing five well known based on their exact confidence coefficient and average coverage probability.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Statistics in Biopharmaceutical Research
سال: 2009
ISSN: 1946-6315
DOI: 10.1198/sbr.2009.0001